2-Chloro-5-chloromethylthiazole
name: 2-chloro-5-chloromethyl thiazole
The molecular formula is C4H3NSCl2.
Molecular weight: 168
Structural formula:
Appearance: pale yellow crystal or pale yellow liquid.
Content: ≥98%
Melting point: 29-31℃
Packing: 250kg/plastic bucket
Uses: Pharmaceutical intermediates. Pesticide intermediates
Used in the synthesis of pesticide clothianidin, clothianidin and medicine ritonavir. At present, thiamethoxam, as a new generation of nicotine insecticide, has attracted the attention of pesticide industry and has a good market prospect. As an inhibitor of human immunodeficiency virus (HIV), tonavir is indispensable without specific drugs.
Preparation method:
The preparation method comprises the following steps: adding 2- chloropropenyl isothiocyanate and solvent chloroform into a reaction bottle, then dropwise adding thionyl chloride, keeping the internal temperature at 30℃, and then reacting at room temperature for 2.5h, when the internal temperature rises to 36℃. After the reaction, the solvent and the remaining thionyl chloride are distilled off, the residue is dissolved in dichloromethane, washed and dried with NaHCO3 solution and water respectively, and the solvent is distilled off (under reduced pressure) to obtain the product.
